Kevin Kastner

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Nieuwland 384K

Research

Kevin creates homology models of G-Protein Coupled Receptors (GPCRs) and studies Molecular Dynamics (MD) simulations of them in order to establish a better understanding of this frequently drug-targeted, yet not fully realized family of proteins. He is specifically targeting GPCRs located in mosquitoes to aid in the development of insecticides in the fight against malaria. Using virtual screening, coupled with MD simulations, he finds novel GPCR compounds that can then be tested experimentally. Kevin's cross-disciplinary work was in the lab of Dr. Roger Sunahara at the University of Michigan to produce binding assays which will be crucial in understanding how the ligands bind to the active site, as well as creating X-ray crystal structures to verify the homology models.

Education

Present - Graduate Student - University of Notre Dame, Notre Dame, IN

2008 - M.S. Computer Science - Baylor University, Waco, TX

2006 - B.S. Bioinformatics - Baylor University, Waco, TX

Honors/Awards

CBBI Fellowship (University of Notre Dame, 2012-Present)

Honor’s Program (Baylor University, 2002-2004)

Dean’s List [3.75/4.00] (Baylor University, 5 semesters)

Member, National Society of Collegiate Scholars

Member, Golden Key International Honour Society

Publications

In preparation: Kastner, K., Estiu, G., Sunahara, R., Shoue, D., Markley, L., McDowell, M., Izaguirre, J.; Virtual Screening of the A. gambiae Octopamine Receptor

In preparation: Kastner, K., Estiu, G., Izaguirre, J.; Using QM/MM to Determine the Agonist Active Site of the A. gambiae Octopamine Receptor

Last Updated on Thursday, 08 November 2012 17:55